Low MHC variation in the polar bear: implications in the face of Arctic warming?
Identifieur interne : 000F82 ( Main/Exploration ); précédent : 000F81; suivant : 000F83Low MHC variation in the polar bear: implications in the face of Arctic warming?
Auteurs : D. S. Weber [États-Unis] ; P. J. Van Coeverden De Groot [Canada] ; E. Peacock [Canada, États-Unis] ; M. D. Schrenzel [États-Unis] ; D. A. Perez [États-Unis] ; S. Thomas [États-Unis] ; J. M. Shelton [États-Unis] ; C. K. Else [États-Unis] ; L. L. Darby [États-Unis] ; L. Acosta [États-Unis] ; C. Harris [Canada] ; J. Youngblood [États-Unis] ; P. Boag [Canada] ; R. Desalle [États-Unis]Source :
- Animal Conservation [ 1367-9430 ] ; 2013-12.
Abstract
Animals in the Arctic have low pathogen diversity but with rapid climate warming, this is expected to change. One insidious consequence of climate change is exposure of Arctic species to new pathogens derived from more southern species expanding their range northward. To assess potential vulnerability of polar bears to disease exposure, we examined genetic variation in major histocompatibility complex (MHC) loci (part of immune system) in Canadian polar bears and found low genetic diversity, consistent with long‐standing exposure to low pathogen/parasite loads. All polar bears surveyed showed maximum linkage disequilibrium between DRB/DQB loci and 12% of individuals had a duplicated DQB gene haplotype. These results may reflect balancing selection at these loci, a response to an earlier immune‐challenge and/or be artifacts of polar bear‐brown bear divergence. Consistent with the latter, we found one DQA allele in polar bears that was also a brown bear DQA allele. The reported low MHC diversity and high linkage disequilibrium may have serious implications for polar bear resistance to new pathogens, which would be maladaptive to species in an environment undergoing rapid climate change, such as the Arctic.
Url:
DOI: 10.1111/acv.12045
Affiliations:
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Youngblood</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>San Diego Zoo Institute for Conservation Research, CA, Escondido</wicri:regionArea><wicri:noRegion>Escondido</wicri:noRegion></affiliation></author><author><name sortKey="Boag, P" sort="Boag, P" uniqKey="Boag P" first="P." last="Boag">P. Boag</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Biology Department, Queen's University, ON, Kingston</wicri:regionArea><wicri:noRegion>Kingston</wicri:noRegion></affiliation></author><author><name sortKey="Desalle, R" sort="Desalle, R" uniqKey="Desalle R" first="R." last="Desalle">R. Desalle</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>American Museum of Natural History, NY, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Animal Conservation</title><title level="j" type="abbrev">Anim Conserv</title><idno type="ISSN">1367-9430</idno><idno type="eISSN">1469-1795</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><date type="published" when="2013-12">2013-12</date><biblScope unit="volume">16</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="671">671</biblScope><biblScope unit="page" to="683">683</biblScope></imprint><idno type="ISSN">1367-9430</idno></series><idno type="istex">6CF9A18074497FCB88F97BA04A9C8C6E03B14962</idno><idno type="DOI">10.1111/acv.12045</idno><idno type="ArticleID">ACV12045</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1367-9430</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Animals in the Arctic have low pathogen diversity but with rapid climate warming, this is expected to change. One insidious consequence of climate change is exposure of Arctic species to new pathogens derived from more southern species expanding their range northward. To assess potential vulnerability of polar bears to disease exposure, we examined genetic variation in major histocompatibility complex (MHC) loci (part of immune system) in Canadian polar bears and found low genetic diversity, consistent with long‐standing exposure to low pathogen/parasite loads. All polar bears surveyed showed maximum linkage disequilibrium between DRB/DQB loci and 12% of individuals had a duplicated DQB gene haplotype. These results may reflect balancing selection at these loci, a response to an earlier immune‐challenge and/or be artifacts of polar bear‐brown bear divergence. Consistent with the latter, we found one DQA allele in polar bears that was also a brown bear DQA allele. The reported low MHC diversity and high linkage disequilibrium may have serious implications for polar bear resistance to new pathogens, which would be maladaptive to species in an environment undergoing rapid climate change, such as the Arctic.</div></front></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Floride</li><li>État de New York</li></region><settlement><li>New York</li></settlement><orgName><li>Université Columbia</li></orgName></list><tree><country name="États-Unis"><region name="Floride"><name sortKey="Weber, D S" sort="Weber, D S" uniqKey="Weber D" first="D. S." last="Weber">D. S. Weber</name></region><name sortKey="Acosta, L" sort="Acosta, L" uniqKey="Acosta L" first="L." last="Acosta">L. Acosta</name><name sortKey="Acosta, L" sort="Acosta, L" uniqKey="Acosta L" first="L." last="Acosta">L. Acosta</name><name sortKey="Darby, L L" sort="Darby, L L" uniqKey="Darby L" first="L. L." last="Darby">L. L. Darby</name><name sortKey="Darby, L L" sort="Darby, L L" uniqKey="Darby L" first="L. L." last="Darby">L. L. Darby</name><name sortKey="Desalle, R" sort="Desalle, R" uniqKey="Desalle R" first="R." last="Desalle">R. Desalle</name><name sortKey="Else, C K" sort="Else, C K" uniqKey="Else C" first="C. K." last="Else">C. K. Else</name><name sortKey="Else, C K" sort="Else, C K" uniqKey="Else C" first="C. K." last="Else">C. K. Else</name><name sortKey="Peacock, E" sort="Peacock, E" uniqKey="Peacock E" first="E." last="Peacock">E. Peacock</name><name sortKey="Perez, D A" sort="Perez, D A" uniqKey="Perez D" first="D. A." last="Perez">D. A. Perez</name><name sortKey="Perez, D A" sort="Perez, D A" uniqKey="Perez D" first="D. A." last="Perez">D. A. Perez</name><name sortKey="Schrenzel, M D" sort="Schrenzel, M D" uniqKey="Schrenzel M" first="M. D." last="Schrenzel">M. D. Schrenzel</name><name sortKey="Shelton, J M" sort="Shelton, J M" uniqKey="Shelton J" first="J. M." last="Shelton">J. M. Shelton</name><name sortKey="Shelton, J M" sort="Shelton, J M" uniqKey="Shelton J" first="J. M." last="Shelton">J. M. Shelton</name><name sortKey="Shelton, J M" sort="Shelton, J M" uniqKey="Shelton J" first="J. M." last="Shelton">J. M. Shelton</name><name sortKey="Thomas, S" sort="Thomas, S" uniqKey="Thomas S" first="S." last="Thomas">S. Thomas</name><name sortKey="Weber, D S" sort="Weber, D S" uniqKey="Weber D" first="D. S." last="Weber">D. S. Weber</name><name sortKey="Youngblood, J" sort="Youngblood, J" uniqKey="Youngblood J" first="J." last="Youngblood">J. Youngblood</name></country><country name="Canada"><noRegion><name sortKey="Van Coeverden De Groot, P J" sort="Van Coeverden De Groot, P J" uniqKey="Van Coeverden De Groot P" first="P. J." last="Van Coeverden De Groot">P. J. Van Coeverden De Groot</name></noRegion><name sortKey="Boag, P" sort="Boag, P" uniqKey="Boag P" first="P." last="Boag">P. Boag</name><name sortKey="Harris, C" sort="Harris, C" uniqKey="Harris C" first="C." last="Harris">C. Harris</name><name sortKey="Peacock, E" sort="Peacock, E" uniqKey="Peacock E" first="E." last="Peacock">E. Peacock</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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